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Metformin And Weight Loss Clinical Trials.

By Harris Stackpole


Metformin is also known by its generic name, Glucophage. It was initially marketed to help Type II diabetics to lose weight quickly. Type II diabetes is much improved when the patient is no longer obese. It was discovered that Metformin could also help non-diabetics lose weight too. For non-diabetics the greatest weight loss success occurred when Metformin was used in conjunction with a healthy diet and a reasonable exercise program.

Metformin governs the amount of sugar in the body and how it is absorbed by the tissues. It does this in three ways. First, it stabilizes the amount of sugar in the blood. Second, slows the production of glucose by the liver. Finally, Metformin heightens the level of sensitivity the tissues have to insulin.

Metformin has been used for years to address mental health issues as well. When someone has gained significant weight because of taking an antidepressant, Metformin is very successful in helping them lose this added weight. The periodical Redbook printed the results of a study that showed the vast majority of the participants lost ten percent of their weight while taking Metformin. Other studies are more specific and report that study participants lost as much as thirty pounds as a result of Metformin.

Here's how Metformin works. Insulin is the culprit that causes weight gain. After we eat a meal our blood sugar rises. This stimulates the liver to pump insulin into the blood. The increasing insulin gives us a hunger message which moves us to eat. But, when we eat, sugar is dumped into the blood and the cycle continues.

Avoiding foods laden with refined sugars and carbohydrates, like breads and sweets, is an early step in preventing weight gain and obesity. It's also the first step in losing weight. Processed carbohydrates are trigger foods that cause the blood sugar to quickly spike and fall.

When we have eaten, the meal is broken down and sugar enters the intestines and then our blood, and then our liver. The liver then releases the sugar back into the bloodstream which triggers the pancreas to produce insulin to keep the blood sugar from rising high enough to damage nerve tissues, the kidneys and the heart.

When insulin lowers the blood sugar, the brain gets a hunger signal. This makes us eat which starts the process over again. Eating dumps sugar into the blood which makes the pancreas dump insulin into the blood to protect the organs and lowers the blood sugar. Metformin breaks this cycle by preventing the pancreas from manufacturing excess insulin. In this way, Metformin keeps us from getting as hungry so we don't eat as often.

Metformin, like any medication, has benefits, risks and drug interactions. Be sure you understand this balance before you take Metformin for weight loss. Speak to your doctor to determine if Metformin is your best choice for weight loss. Also, consider which lifestyle changes you can make to reach your weight loss goals.




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